Quantitation of Fluphenazine in Equine Serum Following Fluphenazine Decanoate Administration
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چکیده
منابع مشابه
Quantitation of fluphenazine in equine serum following fluphenazine decanoate administration.
Fluphenazine, a potent antipsychotic used to treat schizophrenia in humans, is used in racehorses as a performance-enhancing drug, and for that reason it has been banned by the Association of Racing Commissioners International. A liquid chromatography-tandem mass spectrometry method for detecting and quantitating fluphenazine in equine serum was developed and validated. The method was then empl...
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Introduction of chlorpromazine by Delay and Danikcr in 1952 revolutionized the treatment of acute schizophrenia. However, chronic form of the illness still remains a challenge, mainly because of noncompliance of the patients with the therapeutic regimen (Diamond and Marks, 1960; Olson and Peterson, 1960; Hare and Willcox, 1967 ; Wilson and Enoch, 1967 and Ayd, 1975). Another factor is the errat...
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A single injection of fluphenazine decanoate (FD) antagonized effects of acute d-amphetamine (2.5 mg/kg) for a variable period of time (4 to 28 days), depending upon the dosage of the neurolcptic used (2.5 or 5.0 mg/kg) and the behavioural parameter(s) monitored. Locomotion and rearing were antagonized for a longer duration than was sniffing. Normal locomotor response to amphetamine was attaine...
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متن کاملFluphenazine dihydrochloride dimethanol solvate
In the title compound {systematic name: 1-(2-hy-droxy-eth-yl)-4-[3-(2-trifluoro-methyl-10H-phenothia-zin-10-yl)prop-yl]piperazine-1,4-diium dichloride dimethanol disolvate}, C(22)H(28)F(3)N(3)OS(2+)·2Cl(-)·2CH(3)OH, the dihedral angle between the planes of the two outer benzene rings of the tricyclic phenothia-zine system is 46.91 (13)°. The piperazine ring adopts a chair conformation. The crys...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2013
ISSN: 1945-2403,0146-4760
DOI: 10.1093/jat/bkt073